{"entity":{"id":"klhl14","kind":"target","name":"KLHL14","aka":["kelch like family member 14","Kelch-like protein 14","KIAA1384"],"tldr":"KLHL14 (Kelch-like protein 14) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"UniProt has no function text for Q9P2G3; HGNC names it \"kelch like family member 14\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29266","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29266"},{"label":"UniProt Q9P2G3","url":"https://www.uniprot.org/uniprotkb/Q9P2G3/entry"},{"label":"NCBI Gene 57565","url":"https://www.ncbi.nlm.nih.gov/gene/57565"},{"label":"Ensembl ENSG00000197705","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197705"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLHL14","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:29266","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29266","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P2G3","url":"https://www.uniprot.org/uniprotkb/Q9P2G3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KLHL14","url":"https://civicdb.org/features/13880","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"hgnc":"HGNC:29266","ensembl":"ENSG00000197705","uniprot":"Q9P2G3","entrez":"57565","biology":"UniProt has no function text for Q9P2G3; HGNC names it \"kelch like family member 14\". Location: Cytoplasm, cytosol; Endoplasmic reticulum membrane (UniProt). Locus 18q12.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/klhl14/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}