{"entity":{"id":"kmt5a","kind":"target","name":"KMT5A","aka":["lysine methyltransferase 5A","N-lysine methyltransferase KMT5A","SET8","SET07","PR-Set7","SETD8"],"tldr":"KMT5A (N-lysine methyltransferase KMT5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.","summary":"Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Invasive Breast Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29489"},{"label":"UniProt Q9NQR1","url":"https://www.uniprot.org/uniprotkb/Q9NQR1/entry"},{"label":"NCBI Gene 387893","url":"https://www.ncbi.nlm.nih.gov/gene/387893"},{"label":"Ensembl ENSG00000183955","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183955"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KMT5A","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29489","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NQR1","url":"https://www.uniprot.org/uniprotkb/Q9NQR1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen KMT5A","url":"https://www.intogen.org/search?gene=KMT5A","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29489","ensembl":"ENSG00000183955","uniprot":"Q9NQR1","entrez":"387893","biology":"Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Location: Nucleus; Chromosome (UniProt). Locus 12q24.31 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 1 cohort (BRCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/kmt5a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}