{"entity":{"id":"knstrn","kind":"target","name":"KNSTRN","aka":["kinetochore localized astrin (SPAG5) binding protein","Small kinetochore-associated protein","FLJ14502","kinastrin","TRAF4AF1","C15orf23"],"tldr":"KNSTRN (Small kinetochore-associated protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.","summary":"Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cutaneous Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30767","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30767"},{"label":"UniProt Q9Y448","url":"https://www.uniprot.org/uniprotkb/Q9Y448/entry"},{"label":"NCBI Gene 90417","url":"https://www.ncbi.nlm.nih.gov/gene/90417"},{"label":"Ensembl ENSG00000128944","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128944"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KNSTRN","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30767","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30767","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y448","url":"https://www.uniprot.org/uniprotkb/Q9Y448/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen KNSTRN","url":"https://www.intogen.org/search?gene=KNSTRN","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30767","ensembl":"ENSG00000128944","uniprot":"Q9Y448","entrez":"90417","biology":"Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidence. Location: Nucleus; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle pole; Cytoplasm, cytoskeleton, microtubule organizing center (UniProt). Locus 15q15.1 (HGNC).","whereFound":["Melanoma: IntOGen driver in 1 cohort (SKCM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/knstrn/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}