{"entity":{"id":"kr-402","kind":"drug","name":"KR-402","aka":[],"tldr":"KR-402 is an experimental in vivo CAR-T: mRNA in T-cell-targeted lipid nanoparticles from Kernal Biologics, in preclinical development for cancer.","summary":"KR-402 is an in vivo CAR-T: mRNA in T-cell-targeted lipid nanoparticles from Kernal Biologics. A programme that uses T-cell-targeted lipid nanoparticles carrying mRNA to programme CAR-T cells directly inside the body; the company reports B-cell depletion within a week. Its furthest stage is preclinical development, for cancer. No clinical trial naming it is registered on ClinicalTrials.gov. No registered trial found on ClinicalTrials.gov for KR-402 or KR402 (checked 3 Nov 2026). The CAR target antigen is not stated in any source read. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"Kernal Biologics: ycombinator.com","url":"https://www.ycombinator.com/companies/kernal-biologics"},{"label":"Kernal Biologics: kernalbio.com","url":"https://www.kernalbio.com"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["kernal-biologics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"KR-402","modality":"In vivo CAR-T: mRNA in T-cell-targeted lipid nanoparticles","mechanism":"A programme that uses T-cell-targeted lipid nanoparticles carrying mRNA to programme CAR-T cells directly inside the body; the company reports B-cell depletion within a week.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/kr-402/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"kernal-biologics","kind":"company","name":"Kernal Biologics","route":"/companies/kernal-biologics/"}]}}