{"entity":{"id":"ksr1","kind":"target","name":"KSR1","aka":["kinase suppressor of ras 1","Kinase suppressor of Ras 1","RSU2"],"tldr":"KSR1 (Kinase suppressor of Ras 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Part of a multiprotein signalling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.97, animal model 0.57, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6465","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6465"},{"label":"UniProt Q8IVT5","url":"https://www.uniprot.org/uniprotkb/Q8IVT5/entry"},{"label":"NCBI Gene 8844","url":"https://www.ncbi.nlm.nih.gov/gene/8844"},{"label":"Ensembl ENSG00000141068","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141068"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KSR1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6465","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6465","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IVT5","url":"https://www.uniprot.org/uniprotkb/Q8IVT5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141068","url":"https://platform.opentargets.org/target/ENSG00000141068/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6465","ensembl":"ENSG00000141068","uniprot":"Q8IVT5","entrez":"8844","biology":"Part of a multiprotein signalling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. Location: Cytoplasm; Membrane; Cell membrane; Cell projection, ruffle membrane (UniProt). Locus 17q11.2 (HGNC).","whereFound":[],"targetClass":"kinase","prevalence":[]},"route":"/targets/ksr1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}