{"entity":{"id":"ksr2","kind":"target","name":"KSR2","aka":["kinase suppressor of ras 2","Kinase suppressor of Ras 2","FLJ25965"],"tldr":"KSR2 (Kinase suppressor of Ras 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.97, genetic association 0.47).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18610","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18610"},{"label":"UniProt Q6VAB6","url":"https://www.uniprot.org/uniprotkb/Q6VAB6/entry"},{"label":"NCBI Gene 283455","url":"https://www.ncbi.nlm.nih.gov/gene/283455"},{"label":"Ensembl ENSG00000171435","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171435"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KSR2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18610","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18610","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6VAB6","url":"https://www.uniprot.org/uniprotkb/Q6VAB6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000171435","url":"https://platform.opentargets.org/target/ENSG00000171435/associations","note":"association with cancer (MONDO_0004992) 0.69;  (GraphQL API, CC0)"}],"hgnc":"HGNC:18610","ensembl":"ENSG00000171435","uniprot":"Q6VAB6","entrez":"283455","biology":"Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signalling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Location: Cytoplasm; Membrane (UniProt). Locus 12q24.22-q24.23 (HGNC).","whereFound":[],"targetClass":"kinase","prevalence":[]},"route":"/targets/ksr2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}