{"entity":{"id":"ktn1","kind":"target","name":"KTN1","aka":["kinectin 1","Kinectin","KIAA0004","CG1"],"tldr":"KTN1 (Kinectin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.03, somatic mutation 0.92).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6467","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6467"},{"label":"UniProt Q86UP2","url":"https://www.uniprot.org/uniprotkb/Q86UP2/entry"},{"label":"NCBI Gene 3895","url":"https://www.ncbi.nlm.nih.gov/gene/3895"},{"label":"Ensembl ENSG00000126777","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126777"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KTN1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6467","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6467","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86UP2","url":"https://www.uniprot.org/uniprotkb/Q86UP2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000126777","url":"https://platform.opentargets.org/target/ENSG00000126777/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6467","ensembl":"ENSG00000126777","uniprot":"Q86UP2","entrez":"3895","biology":"Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Location: Endoplasmic reticulum membrane (UniProt). Locus 14q22.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ktn1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}