{"entity":{"id":"l3mbtl3","kind":"target","name":"L3MBTL3","aka":["L3MBTL histone methyl-lysine binding protein 3","Lethal(3)malignant brain tumor-like protein 3","KIAA1798"],"tldr":"L3MBTL3 (Lethal(3)malignant brain tumour-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23035","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23035"},{"label":"UniProt Q96JM7","url":"https://www.uniprot.org/uniprotkb/Q96JM7/entry"},{"label":"NCBI Gene 84456","url":"https://www.ncbi.nlm.nih.gov/gene/84456"},{"label":"Ensembl ENSG00000198945","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198945"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"L3MBTL3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23035","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23035","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96JM7","url":"https://www.uniprot.org/uniprotkb/Q96JM7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198945","url":"https://platform.opentargets.org/target/ENSG00000198945/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:23035","ensembl":"ENSG00000198945","uniprot":"Q96JM7","entrez":"84456","biology":"Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells. Location: Nucleus (UniProt). Locus 6q23.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/l3mbtl3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}