{"entity":{"id":"lama5","kind":"target","name":"LAMA5","aka":["laminin subunit alpha 5","Laminin subunit alpha-5"],"tldr":"LAMA5 (Laminin subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signalling and PTK2B/PYK2.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.89, animal model 0.44, genetic association 0.64, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6485","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6485"},{"label":"UniProt O15230","url":"https://www.uniprot.org/uniprotkb/O15230/entry"},{"label":"NCBI Gene 3911","url":"https://www.ncbi.nlm.nih.gov/gene/3911"},{"label":"Ensembl ENSG00000130702","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130702"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LAMA5","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6485","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6485","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15230","url":"https://www.uniprot.org/uniprotkb/O15230/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000130702","url":"https://platform.opentargets.org/target/ENSG00000130702/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6485","ensembl":"ENSG00000130702","uniprot":"O15230","entrez":"3911","biology":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signalling and PTK2B/PYK2. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 20q13.33 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lama5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}