{"entity":{"id":"lamc1","kind":"target","name":"LAMC1","aka":["laminin subunit gamma 1","Laminin subunit gamma-1","LAMB2"],"tldr":"LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.96, animal model 0.44, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6492","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6492"},{"label":"UniProt P11047","url":"https://www.uniprot.org/uniprotkb/P11047/entry"},{"label":"NCBI Gene 3915","url":"https://www.ncbi.nlm.nih.gov/gene/3915"},{"label":"Ensembl ENSG00000135862","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135862"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LAMC1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6492","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6492","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P11047","url":"https://www.uniprot.org/uniprotkb/P11047/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000135862","url":"https://platform.opentargets.org/target/ENSG00000135862/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6492","ensembl":"ENSG00000135862","uniprot":"P11047","entrez":"3915","biology":"Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 1q25.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lamc1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}