{"entity":{"id":"lats2","kind":"target","name":"LATS2","aka":["large tumor suppressor kinase 2","Serine/threonine-protein kinase LATS2"],"tldr":"LATS2 (Serine/threonine-protein kinase LATS2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Skin cancer, Colorectal cancer and 5 more.","summary":"Negative regulator of YAP1 in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 5 cohorts (1 activating, 4 loss-of-function), covering Lung Squamous Cell Carcinoma, Pilocytic Astrocytoma, Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6515","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6515"},{"label":"UniProt Q9NRM7","url":"https://www.uniprot.org/uniprotkb/Q9NRM7/entry"},{"label":"NCBI Gene 26524","url":"https://www.ncbi.nlm.nih.gov/gene/26524"},{"label":"Ensembl ENSG00000150457","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000150457"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["mesothelioma","skin-cancer","colorectal","breast-cancer","pleural-mesothelioma","nsclc","paediatric-low-grade-glioma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LATS2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6515","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6515","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NRM7","url":"https://www.uniprot.org/uniprotkb/Q9NRM7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000150457","url":"https://platform.opentargets.org/target/ENSG00000150457/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.50, skin cancer 0.55, breast cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen LATS2","url":"https://www.intogen.org/search?gene=LATS2","note":"driver in 5 cohorts (Act 1, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6515","ensembl":"ENSG00000150457","uniprot":"Q9NRM7","entrez":"26524","biology":"Negative regulator of YAP1 in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation. Acts as a tumour suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm; Cytoplasm, cytoskeleton, spindle pole; Nucleus (UniProt). Locus 13q12.11 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 3 cohorts (PLMESO)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Pleural mesothelioma: IntOGen driver in 3 cohorts (PLMESO)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/lats2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}