{"entity":{"id":"lck","kind":"target","name":"LCK","aka":["LCK proto-oncogene, Src family tyrosine kinase","Tyrosine-protein kinase Lck"],"tldr":"LCK (Tyrosine-protein kinase Lck) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a fusion partner, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Renal cell carcinoma, Myeloproliferative neoplasms and 5 more.","summary":"Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors.\n\nOpen Targets scores its association with cancer at 0.81 (direct and indirect evidence; datatypes clinical 0.98, affected pathway 0.92, literature 0.95, genetic association 0.00, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6524","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6524"},{"label":"UniProt P06239","url":"https://www.uniprot.org/uniprotkb/P06239/entry"},{"label":"NCBI Gene 3932","url":"https://www.ncbi.nlm.nih.gov/gene/3932"},{"label":"Ensembl ENSG00000182866","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182866"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","rcc","myeloproliferative-neoplasms","non-hodgkin-lymphoma","sarcoma","skin-cancer","ovarian","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LCK","role":["drug-target","fusion-partner"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6524","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6524","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P06239","url":"https://www.uniprot.org/uniprotkb/P06239/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000182866","url":"https://platform.opentargets.org/target/ENSG00000182866/associations","note":"association with cancer (MONDO_0004992) 0.81; per-cancer scores at or above 0.5: renal cell carcinoma 0.67, ovarian cancer 0.55, melanoma 0.53, sarcoma 0.62, acute lymphoblastic leukaemia 0.64, non-Hodgkin lymphoma 0.64 (GraphQL API, CC0)"}],"hgnc":"HGNC:6524","ensembl":"ENSG00000182866","uniprot":"P06239","entrez":"3932","biology":"Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR-CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR-CD3 signalling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Location: Cell membrane; Cytoplasm, cytosol (UniProt). Locus 1p35.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.69 with leukaemia (MONDO_0005059)","Renal cell carcinoma: Open Targets association 0.67 with renal cell carcinoma (MONDO_0005086)","Myeloproliferative neoplasms: Open Targets association 0.66 with myeloproliferative neoplasm (MONDO_0020076)","Non-Hodgkin lymphoma: Open Targets association 0.64 with non-Hodgkin lymphoma (MONDO_0018908)","Sarcomas: Open Targets association 0.62 with sarcoma (MONDO_0005089)","Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/lck/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}