{"entity":{"id":"ldb1","kind":"target","name":"LDB1","aka":["LIM domain binding 1","LIM domain-binding protein 1","CLIM2"],"tldr":"LDB1 (LIM domain-binding protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.","summary":"Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1.\n\nIntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6532","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6532"},{"label":"UniProt Q86U70","url":"https://www.uniprot.org/uniprotkb/Q86U70/entry"},{"label":"NCBI Gene 8861","url":"https://www.ncbi.nlm.nih.gov/gene/8861"},{"label":"Ensembl ENSG00000198728","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198728"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma","paediatric-low-grade-glioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LDB1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6532","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6532","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86U70","url":"https://www.uniprot.org/uniprotkb/Q86U70/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen LDB1","url":"https://www.intogen.org/search?gene=LDB1","note":"driver in 3 cohorts (Act 0, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6532","ensembl":"ENSG00000198728","uniprot":"Q86U70","entrez":"8861","biology":"Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Location: Nucleus (UniProt). Locus 10q24.32 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 2 cohorts (MBL)","Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ldb1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"}]}}