{"entity":{"id":"lef1","kind":"target","name":"LEF1","aka":["lymphoid enhancer binding factor 1","Lymphoid enhancer-binding factor 1","TCF1ALPHA","TCF10","TCF7L3"],"tldr":"LEF1 (Lymphoid enhancer-binding factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Non-Hodgkin lymphoma, Hepatocellular carcinoma and 3 more.","summary":"Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.99, animal model 0.67, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Hepatocellular Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6551","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6551"},{"label":"UniProt Q9UJU2","url":"https://www.uniprot.org/uniprotkb/Q9UJU2/entry"},{"label":"NCBI Gene 51176","url":"https://www.ncbi.nlm.nih.gov/gene/51176"},{"label":"Ensembl ENSG00000138795","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138795"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["leukaemia","non-hodgkin-lymphoma","hcc","skin-cancer","breast-cancer","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LEF1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6551","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6551","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UJU2","url":"https://www.uniprot.org/uniprotkb/Q9UJU2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138795","url":"https://platform.opentargets.org/target/ENSG00000138795/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.59, non-Hodgkin lymphoma 0.59, skin cancer 0.53, breast cancer 0.52, leukaemia 0.61 (GraphQL API, CC0)"},{"label":"IntOGen LEF1","url":"https://www.intogen.org/search?gene=LEF1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6551","ensembl":"ENSG00000138795","uniprot":"Q9UJU2","entrez":"51176","biology":"Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signalling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIAG antagonises both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Location: Nucleus (UniProt). Locus 4q25 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.61 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)","Acute lymphoblastic leukaemia: Open Targets association 0.59 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/lef1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}