{"entity":{"id":"lmo1","kind":"target","name":"LMO1","aka":["LIM domain only 1","Rhombotin-1","TTG1","RHOM1","RBTN1"],"tldr":"LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.37, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6641","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6641"},{"label":"UniProt P25800","url":"https://www.uniprot.org/uniprotkb/P25800/entry"},{"label":"NCBI Gene 4004","url":"https://www.ncbi.nlm.nih.gov/gene/4004"},{"label":"Ensembl ENSG00000166407","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166407"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LMO1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6641","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6641","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P25800","url":"https://www.uniprot.org/uniprotkb/P25800/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000166407","url":"https://platform.opentargets.org/target/ENSG00000166407/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:6641","ensembl":"ENSG00000166407","uniprot":"P25800","entrez":"4004","biology":"May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Location: Nucleus (UniProt). Locus 11p15.4 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)"],"targetClass":"other","prevalence":[]},"route":"/targets/lmo1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}