{"entity":{"id":"lmo2","kind":"target","name":"LMO2","aka":["LIM domain only 2","Rhombotin-2","TTG2","RHOM2","RBTN2","RBTNL1"],"tldr":"LMO2 (Rhombotin-2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.\n\nOpen Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes affected pathway 0.35, literature 0.93, genetic association 0.03, somatic mutation 0.96, animal model 0.52).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6642","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6642"},{"label":"UniProt P25791","url":"https://www.uniprot.org/uniprotkb/P25791/entry"},{"label":"NCBI Gene 4005","url":"https://www.ncbi.nlm.nih.gov/gene/4005"},{"label":"Ensembl ENSG00000135363","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135363"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LMO2","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6642","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6642","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P25791","url":"https://www.uniprot.org/uniprotkb/P25791/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000135363","url":"https://platform.opentargets.org/target/ENSG00000135363/associations","note":"association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:6642","ensembl":"ENSG00000135363","uniprot":"P25791","entrez":"4005","biology":"Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. Location: Nucleus (UniProt). Locus 11p13 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)"],"targetClass":"other","prevalence":[]},"route":"/targets/lmo2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}