{"entity":{"id":"lmx1b","kind":"target","name":"LMX1B","aka":["LIM homeobox transcription factor 1 beta","LIM homeobox transcription factor 1-beta","NPS1"],"tldr":"LMX1B (LIM homeobox transcription factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.80, animal model 0.69, genetic association 0.62).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6654","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6654"},{"label":"UniProt O60663","url":"https://www.uniprot.org/uniprotkb/O60663/entry"},{"label":"NCBI Gene 4010","url":"https://www.ncbi.nlm.nih.gov/gene/4010"},{"label":"Ensembl ENSG00000136944","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136944"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LMX1B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6654","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6654","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O60663","url":"https://www.uniprot.org/uniprotkb/O60663/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136944","url":"https://platform.opentargets.org/target/ENSG00000136944/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6654","ensembl":"ENSG00000136944","uniprot":"O60663","entrez":"4010","biology":"Transcription factor involved in the regulation of podocyte-expressed genes. Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Location: Nucleus (UniProt). Locus 9q33.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/lmx1b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}