{"entity":{"id":"logistic-regression-term","kind":"term","name":"Logistic regression and nearest-centroid classifiers","aka":["logistic regression","logistic classifier","nearest-centroid classifier","nearest centroid","centroid classifier","PAM50 centroid correlation","rank-based PAM50"],"tldr":"Logistic regression is the plain linear classifier used as a baseline for subtype prediction; a nearest-centroid classifier instead assigns each sample to the subtype whose average profile it most resembles, which is how PAM50 works.","summary":"Logistic regression models the log-odds of a binary outcome as a linear combination of inputs (Wikipedia); a nearest-centroid classifier assigns the label of the class whose mean (centroid) is closest (Wikipedia). Parker and colleagues' PAM50 predictor correlates a sample's fifty-gene profile with five subtype centroids, and using Spearman correlation on ranks makes it robust to platform, so the same classifier runs on microarray, RNA-seq and spatial pseudobulk. Deep models are compared against these because they often do no better.","asOf":"2026-09-24","wikipedia":"https://en.wikipedia.org/wiki/Logistic_regression","links":[{"label":"Wikipedia: nearest centroid classifier","url":"https://en.wikipedia.org/wiki/Nearest_centroid_classifier"},{"label":"Parker et al., Supervised risk predictor of breast cancer based on intrinsic subtypes (JCO 2009)","url":"https://doi.org/10.1200/JCO.2008.18.1370"},{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Logistic_regression"}],"tags":["cansim-terms"],"related":["cancer-ai-vocabulary"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pam50","linear-probe","ridge-regression","spearman-correlation"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/logistic-regression."],"provenance":{"editedBy":"OnCo CanSim terms wave (Wikipedia summaries, standards and project pages, GDC and FDA pages, Europe PMC)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"category":"Methods and models"},"route":"/terms/logistic-regression-term/","neighbours":{"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"linear-probe","kind":"term","name":"Linear probe","route":"/terms/linear-probe/"},{"id":"pam50","kind":"term","name":"PAM50 / intrinsic subtypes","route":"/terms/pam50/"},{"id":"ridge-regression","kind":"term","name":"Ridge regression and the multilayer perceptron","route":"/terms/ridge-regression/"},{"id":"spearman-correlation","kind":"term","name":"Spearman rank correlation","route":"/terms/spearman-correlation/"}]}}