{"entity":{"id":"lpa","kind":"target","name":"LPA","aka":["lipoprotein(a)","Apolipoprotein(a)","Lp(a)"],"tldr":"LPA (Apolipoprotein(a)) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.","summary":"Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.63, somatic mutation 0.37). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6667","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6667"},{"label":"UniProt P08519","url":"https://www.uniprot.org/uniprotkb/P08519/entry"},{"label":"NCBI Gene 4018","url":"https://www.ncbi.nlm.nih.gov/gene/4018"},{"label":"Ensembl ENSG00000198670","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198670"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LPA","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6667","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6667","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08519","url":"https://www.uniprot.org/uniprotkb/P08519/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198670","url":"https://platform.opentargets.org/target/ENSG00000198670/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"},{"label":"IntOGen LPA","url":"https://www.intogen.org/search?gene=LPA","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6667","ensembl":"ENSG00000198670","uniprot":"P08519","entrez":"4018","biology":"Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. Locus 6q25.3-q26 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/lpa/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}