{"entity":{"id":"lpp","kind":"target","name":"LPP","aka":["LIM domain containing preferred translocation partner in lipoma","Lipoma-preferred partner"],"tldr":"LPP (Lipoma-preferred partner) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Non-Hodgkin lymphoma and 4 more.","summary":"May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites.\n\nOpen Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes literature 0.93, animal model 0.56, genetic association 0.79, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6679","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6679"},{"label":"UniProt Q93052","url":"https://www.uniprot.org/uniprotkb/Q93052/entry"},{"label":"NCBI Gene 4026","url":"https://www.ncbi.nlm.nih.gov/gene/4026"},{"label":"Ensembl ENSG00000145012","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145012"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","breast-cancer","non-hodgkin-lymphoma","leukaemia","gastric","neuroendocrine","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LPP","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6679","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6679","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q93052","url":"https://www.uniprot.org/uniprotkb/Q93052/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000145012","url":"https://platform.opentargets.org/target/ENSG00000145012/associations","note":"association with cancer (MONDO_0004992) 0.78; per-cancer scores at or above 0.5: gastric cancer 0.50, neuroendocrine neoplasm 0.50, non-Hodgkin lymphoma 0.52, skin cancer 0.63, basal cell carcinoma 0.57, breast cancer 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:6679","ensembl":"ENSG00000145012","uniprot":"Q93052","entrez":"4026","biology":"May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signalling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. Location: Nucleus; Cytoplasm; Cell junction; Cell membrane (UniProt). Locus 3q27.3-q28 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.57 with breast cancer (MONDO_0007254)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)","Neuroendocrine tumours: Open Targets association 0.50 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/lpp/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}