{"entity":{"id":"lratd2","kind":"target","name":"LRATD2","aka":["LRAT domain containing 2","BCMP101","NSE2","FAM84B"],"tldr":"LRATD2 (LRAT domain containing 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"UniProt has no function text for Q96KN1; HGNC names it \"LRAT domain containing 2\".\n\nOpen Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.91, animal model 0.32, genetic association 0.77).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24166","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24166"},{"label":"UniProt Q96KN1","url":"https://www.uniprot.org/uniprotkb/Q96KN1/entry"},{"label":"NCBI Gene 157638","url":"https://www.ncbi.nlm.nih.gov/gene/157638"},{"label":"Ensembl ENSG00000168672","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168672"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRATD2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:24166","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24166","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96KN1","url":"https://www.uniprot.org/uniprotkb/Q96KN1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000168672","url":"https://platform.opentargets.org/target/ENSG00000168672/associations","note":"association with cancer (MONDO_0004992) 0.50;  (GraphQL API, CC0)"}],"hgnc":"HGNC:24166","ensembl":"ENSG00000168672","uniprot":"Q96KN1","entrez":"157638","biology":"UniProt has no function text for Q96KN1; HGNC names it \"LRAT domain containing 2\". Locus 8q24.21 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lratd2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}