{"entity":{"id":"lrfn2","kind":"target","name":"LRFN2","aka":["leucine rich repeat and fibronectin type III domain containing 2","Leucine-rich repeat and fibronectin type-III domain-containing protein 2","FIGLER2","KIAA1246","SALM1"],"tldr":"LRFN2 (Leucine-rich repeat and fibronectin type-III domain-containing protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.81, animal model 0.55, genetic association 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21226","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21226"},{"label":"UniProt Q9ULH4","url":"https://www.uniprot.org/uniprotkb/Q9ULH4/entry"},{"label":"NCBI Gene 57497","url":"https://www.ncbi.nlm.nih.gov/gene/57497"},{"label":"Ensembl ENSG00000156564","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156564"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRFN2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:21226","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21226","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9ULH4","url":"https://www.uniprot.org/uniprotkb/Q9ULH4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156564","url":"https://platform.opentargets.org/target/ENSG00000156564/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:21226","ensembl":"ENSG00000156564","uniprot":"Q9ULH4","entrez":"57497","biology":"Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery. Location: Membrane; Synapse; Postsynaptic cell membrane (UniProt). Locus 6p21.2-p21.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lrfn2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}