{"entity":{"id":"lrig3","kind":"target","name":"LRIG3","aka":["leucine rich repeats and immunoglobulin like domains 3","Leucine-rich repeats and immunoglobulin-like domains protein 3","FLJ90440","KIAA3016"],"tldr":"LRIG3 (Leucine-rich repeats and immunoglobulin-like domains protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Lung cancer and Non-small-cell lung cancer.","summary":"May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.03, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30991","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30991"},{"label":"UniProt Q6UXM1","url":"https://www.uniprot.org/uniprotkb/Q6UXM1/entry"},{"label":"NCBI Gene 121227","url":"https://www.ncbi.nlm.nih.gov/gene/121227"},{"label":"Ensembl ENSG00000139263","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139263"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["urothelial","lung-cancer","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRIG3","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30991","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30991","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6UXM1","url":"https://www.uniprot.org/uniprotkb/Q6UXM1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000139263","url":"https://platform.opentargets.org/target/ENSG00000139263/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.53, lung cancer 0.55 (GraphQL API, CC0)"},{"label":"IntOGen LRIG3","url":"https://www.intogen.org/search?gene=LRIG3","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30991","ensembl":"ENSG00000139263","uniprot":"Q6UXM1","entrez":"121227","biology":"May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1. Location: Cell membrane; Cytoplasmic vesicle membrane (UniProt). Locus 12q14.1 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903)","Non-small-cell lung cancer: Open Targets association 0.53 with non-small cell lung carcinoma (MONDO_0005233)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/lrig3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}