{"entity":{"id":"lrk-4189","kind":"drug","name":"LRK-4189","aka":[],"tldr":"LRK-4189 is an experimental targeted protein degrader from Larkspur Biosciences, in phase 1 trials for microsatellite stable colorectal cancer and solid tumours.","summary":"LRK-4189 is a targeted protein degrader (oral, daily) from Larkspur Biosciences. A first-in-class targeted protein degrader of PIP4K2C, a lipid kinase that cancer cells use to survive stress; the company says degrading it triggers cell death through loss of stress adaptations and metabolic failure. Its furthest stage is phase 1, for microsatellite stable colorectal cancer and solid tumours. ClinicalTrials.gov registers it in one study linked below. Dosing began (company news dated 2 Dec 2025); registry phase 1/2, recruiting. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Larkspur Biosciences: larkspur.bio","url":"https://larkspur.bio/our-science/"},{"label":"Larkspur Biosciences: larkspur.bio","url":"https://larkspur.bio/news/"},{"label":"Larkspur Biosciences: clinicaltrials.gov","url":"https://clinicaltrials.gov/api/v2/studies/NCT07498725"},{"label":"ClinicalTrials.gov: trials of LRK-4189","url":"https://clinicaltrials.gov/search?intr=LRK-4189"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["larkspur-biosciences"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07498725"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"LRK-4189","modality":"Targeted protein degrader (oral, daily)","mechanism":"A first-in-class targeted protein degrader of PIP4K2C, a lipid kinase that cancer cells use to survive stress; the company says degrading it triggers cell death through loss of stress adaptations and metabolic failure.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/lrk-4189/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"larkspur-biosciences","kind":"company","name":"Larkspur Biosciences","route":"/companies/larkspur-biosciences/"}],"trial":[{"id":"nct07498725","kind":"trial","name":"A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors","route":"/trials/nct07498725/"}]}}