{"entity":{"id":"lrp1b","kind":"target","name":"LRP1B","aka":["LDL receptor related protein 1B","Low-density lipoprotein receptor-related protein 1B","LRP-DIT","LRPDIT"],"tldr":"LRP1B (Low-density lipoprotein receptor-related protein 1B) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Prostate cancer, Pancreatic ductal adenocarcinoma and 5 more.","summary":"Potential cell surface proteins that bind and internalise ligands in the process of receptor-mediated endocytosis.\n\nCIViC holds 4 clinical evidence items and 0 assertions across 4 variants, naming Immune Checkpoint Inhibitor and Doxorubicin. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.76, genetic association 0.44, somatic mutation 0.88). IntOGen calls it a driver in 70 cohorts (39 activating, 27 loss-of-function), covering Acute Myeloid Leukaemia, Basal Cell Carcinoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6693","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6693"},{"label":"UniProt Q9NZR2","url":"https://www.uniprot.org/uniprotkb/Q9NZR2/entry"},{"label":"NCBI Gene 53353","url":"https://www.ncbi.nlm.nih.gov/gene/53353"},{"label":"Ensembl ENSG00000168702","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168702"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["lung-cancer","prostate","pancreatic","skin-cancer","esophageal","breast-cancer","colorectal","head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; IntOGen calls it an activating (Act) driver in 39 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 27 cohorts; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRP1B","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6693","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6693","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NZR2","url":"https://www.uniprot.org/uniprotkb/Q9NZR2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene LRP1B","url":"https://civicdb.org/features/12146","note":"4 evidence items, 0 assertions, 4 variants; diseases: Glioblastoma, Ovarian Cancer, Lung Adenocarcinoma, Solid Tumour (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000168702","url":"https://platform.opentargets.org/target/ENSG00000168702/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.62, gastric cancer 0.55, oesophageal cancer 0.53, prostate cancer 0.56, ovarian cancer 0.55, melanoma 0.66 (GraphQL API, CC0)"},{"label":"IntOGen LRP1B","url":"https://www.intogen.org/search?gene=LRP1B","note":"driver in 70 cohorts (Act 39, LoF 27); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6693","ensembl":"ENSG00000168702","uniprot":"Q9NZR2","entrez":"53353","biology":"Potential cell surface proteins that bind and internalise ligands in the process of receptor-mediated endocytosis. Location: Membrane (UniProt). Locus 2q22.1-q22.2 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.67 with lung cancer (MONDO_0008903)","Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315); IntOGen driver in 7 cohorts (PRAD)","Pancreatic ductal adenocarcinoma: IntOGen driver in 5 cohorts (PAAD, PANCREAS)","Skin cancer: Open Targets association 0.64 with skin cancer (MONDO_0002898); IntOGen driver in 1 cohort (SKIN)","Oesophageal cancer: Open Targets association 0.53 with oesophageal cancer (MONDO_0007576); IntOGen driver in 4 cohorts (ESCA)","Breast cancer: Open Targets association 0.59 with breast cancer (MONDO_0007254); IntOGen driver in 4 cohorts (BRCA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/lrp1b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}