{"entity":{"id":"lrp5","kind":"target","name":"LRP5","aka":["LDL receptor related protein 5","Low-density lipoprotein receptor-related protein 5","LR3","BMND1","OPTA1","VBCH2","EVR4","LRP7","EVR1"],"tldr":"LRP5 (Low-density lipoprotein receptor-related protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signalling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.91, affected pathway 0.83, animal model 0.60, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6697","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6697"},{"label":"UniProt O75197","url":"https://www.uniprot.org/uniprotkb/O75197/entry"},{"label":"NCBI Gene 4041","url":"https://www.ncbi.nlm.nih.gov/gene/4041"},{"label":"Ensembl ENSG00000162337","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162337"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["wnt"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LRP5","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6697","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6697","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75197","url":"https://www.uniprot.org/uniprotkb/O75197/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000162337","url":"https://platform.opentargets.org/target/ENSG00000162337/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6697","ensembl":"ENSG00000162337","uniprot":"O75197","entrez":"4041","biology":"Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signalling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signalling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilising beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Location: Membrane; Endoplasmic reticulum (UniProt). Locus 11q13.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/lrp5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"pathway":[{"id":"wnt","kind":"pathway","name":"Wnt / β-catenin","route":"/pathways/wnt/"}]}}