{"entity":{"id":"lsm14a","kind":"target","name":"LSM14A","aka":["LSM14A mRNA processing body assembly factor","Protein LSM14 homolog A","DKFZP434D1335","RAP55A","RAP55","C19orf13","FAM61A"],"tldr":"LSM14A (Protein LSM14 homolog A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.","summary":"Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:24489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24489"},{"label":"UniProt Q8ND56","url":"https://www.uniprot.org/uniprotkb/Q8ND56/entry"},{"label":"NCBI Gene 26065","url":"https://www.ncbi.nlm.nih.gov/gene/26065"},{"label":"Ensembl ENSG00000257103","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000257103"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"LSM14A","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:24489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24489","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8ND56","url":"https://www.uniprot.org/uniprotkb/Q8ND56/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen LSM14A","url":"https://www.intogen.org/search?gene=LSM14A","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:24489","ensembl":"ENSG00000257103","uniprot":"Q8ND56","entrez":"26065","biology":"Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly. Location: Cytoplasm, P-body; Cytoplasm, cytoskeleton, spindle; Cytoplasm, Stress granule (UniProt). Locus 19q13.11 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/lsm14a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}