{"entity":{"id":"lymphoma-pit-score","kind":"term","name":"Prognostic Index for T-cell lymphoma (PIT)","aka":["PIT","PIT score","Prognostic Index for PTCL-U","prognostic index for peripheral T-cell lymphoma"],"tldr":"A four-item score that estimates the outlook in nodal T-cell lymphoma, built because the index used for B-cell lymphoma separated these patients poorly. It counts age over 60, a performance status of 2 or worse, a raised lactate dehydrogenase, and lymphoma in the bone marrow.","summary":"The Prognostic Index for T-cell lymphoma was built from 385 patients with peripheral T-cell lymphoma unspecified, classified by the WHO criteria and analysed retrospectively across several Italian centres (Gallamini, Blood 2004). Four features were independently predictive of survival: age over 60 years, a performance status of 2 or worse, a lactate dehydrogenase above the normal range, and bone marrow involvement.\n\nThe four groups it defines had five-year overall survival of 62.3 per cent with no adverse factor, 52.9 per cent with one, and lower with two or more; ten-year survival in the two best groups was 54.9 and 38.8 per cent. Those figures come from patients treated before brentuximab vedotin and before routine transplant consolidation, and they describe a population rather than a person.\n\nIt is used alongside, not instead of, the International Prognostic Index, and it does not change which treatment is given: there is no randomised evidence that a higher score should lead to a different regimen. Its honest use is to set expectations and to stratify trials. A separate index, PINK, exists for extranodal NK/T-cell lymphoma and is described on that page.","asOf":"2026-09-29","links":[{"label":"Peripheral T-cell lymphoma unspecified: the Prognostic Index for T-cell lymphoma (Gallamini, Blood 2004)","url":"https://doi.org/10.1182/blood-2003-09-3080"},{"label":"A predictive model for aggressive non-Hodgkin's lymphoma: the International Prognostic Index (N Engl J Med 1993)","url":"https://doi.org/10.1056/NEJM199309303291402"}],"tags":["heme","lymphoma"],"related":["ipi-score","flipi","mipi"],"cancers":["peripheral-t-cell-lymphoma","angioimmunoblastic-t-cell-lymphoma","non-hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/lymphoma-pit-score/","neighbours":{"term":[{"id":"flipi","kind":"term","name":"FLIPI, FLIPI2 and POD24 (follicular lymphoma risk)","route":"/terms/flipi/"},{"id":"ipi-score","kind":"term","name":"International Prognostic Index (IPI)","route":"/terms/ipi-score/"},{"id":"mipi","kind":"term","name":"MIPI (Mantle Cell Lymphoma International Prognostic Index)","route":"/terms/mipi/"}],"cancer":[{"id":"adult-t-cell-leukaemia-lymphoma","kind":"cancer","name":"Adult T-cell leukaemia/lymphoma","route":"/cancers/adult-t-cell-leukaemia-lymphoma/"},{"id":"alk-negative-anaplastic-large-cell-lymphoma","kind":"cancer","name":"ALK-negative anaplastic large cell lymphoma","route":"/cancers/alk-negative-anaplastic-large-cell-lymphoma/"},{"id":"alk-positive-anaplastic-large-cell-lymphoma","kind":"cancer","name":"ALK-positive anaplastic large cell lymphoma","route":"/cancers/alk-positive-anaplastic-large-cell-lymphoma/"},{"id":"enteropathy-associated-t-cell-lymphoma","kind":"cancer","name":"Enteropathy-associated T-cell lymphoma","route":"/cancers/enteropathy-associated-t-cell-lymphoma/"},{"id":"extranodal-nk-t-cell-lymphoma","kind":"cancer","name":"Extranodal NK/T-cell lymphoma","route":"/cancers/extranodal-nk-t-cell-lymphoma/"},{"id":"monomorphic-epitheliotropic-intestinal-t-cell-lymphoma","kind":"cancer","name":"Monomorphic epitheliotropic intestinal T-cell lymphoma","route":"/cancers/monomorphic-epitheliotropic-intestinal-t-cell-lymphoma/"},{"id":"angioimmunoblastic-t-cell-lymphoma","kind":"cancer","name":"Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma)","route":"/cancers/angioimmunoblastic-t-cell-lymphoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"peripheral-t-cell-lymphoma","kind":"cancer","name":"Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma)","route":"/cancers/peripheral-t-cell-lymphoma/"}]}}