{"entity":{"id":"lymphoma-tx-regimen-alphabet","kind":"term","name":"The lymphoma regimen alphabet: R-CHOP, pola-R-CHP, DA-EPOCH-R, ABVD, BEACOPP and the rest","aka":["Lymphoma chemotherapy acronyms","R-CHP","DA-EPOCH-R","R-ICE","R-DHAP","R-GemOx","CODOX-M/IVAC","MATRix","BrECADD","SMILE","CHOEP","VR-CAP","R-CVP","BR"],"tldr":"Lymphoma treatment is written in acronyms, one letter per drug. This entry spells out the ones a patient will see on a chart or a consent form, and says which disease each belongs to.","summary":"Each acronym is a fixed recipe of drugs given on a fixed schedule, usually in three- or four-week cycles.\n\nAggressive B-cell lymphoma. R-CHOP is rituximab, cyclophosphamide, doxorubicin (hydroxydaunorubicin), vincristine (Oncovin) and prednisolone, every 21 days. Pola-R-CHP swaps vincristine for polatuzumab vedotin. DA-EPOCH-R adds etoposide and gives the cyclophosphamide, doxorubicin and etoposide as a 96-hour infusion with the dose adjusted upward or downward by the neutrophil count in the previous cycle. Salvage regimens before a transplant are R-ICE (ifosfamide, carboplatin, etoposide), R-DHAP (dexamethasone, high-dose cytarabine, cisplatin) and R-GDP (gemcitabine, dexamethasone, cisplatin); R-GemOx (gemcitabine and oxaliplatin) is the gentler outpatient option for people who will never have a transplant.\n\nBurkitt and high-grade disease. CODOX-M/IVAC alternates cyclophosphamide, vincristine, doxorubicin and high-dose methotrexate with ifosfamide, etoposide and high-dose cytarabine. Hyper-CVAD alternates part A (cyclophosphamide, vincristine, doxorubicin, dexamethasone) with part B (high-dose methotrexate and cytarabine). Both are intensive and inpatient; DA-EPOCH-R is the outpatient alternative.\n\nBrain. MATRix is methotrexate, cytarabine, thiotepa and rituximab.\n\nIndolent B-cell. BR is bendamustine and rituximab. R-CVP replaces the doxorubicin of R-CHOP with nothing and keeps cyclophosphamide, vincristine and prednisolone. R-squared, written R2, is rituximab and lenalidomide with no chemotherapy at all.\n\nMantle cell. VR-CAP substitutes bortezomib for vincristine. The Nordic and European young-patient regimens alternate R-CHOP with R-DHAP or use R-maxi-CHOP with high-dose cytarabine before an autologous transplant.\n\nHodgkin lymphoma. ABVD is doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine. AVD is ABVD without the bleomycin. A+AVD adds brentuximab vedotin, N-AVD adds nivolumab. Escalated BEACOPP is bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisolone at increased doses; BrECADD replaces the bleomycin, vincristine and procarbazine with brentuximab vedotin and dacarbazine.\n\nT-cell. CHOP is R-CHOP without the rituximab, because T cells do not carry CD20. CHOEP adds etoposide. A+CHP replaces vincristine with brentuximab vedotin. SMILE is dexamethasone (steroid), methotrexate, ifosfamide, L-asparaginase and etoposide, for extranodal NK/T-cell lymphoma.","asOf":"2026-09-29","links":[{"label":"Alliance/CALGB 50303: DA-EPOCH-R against R-CHOP in DLBCL, Journal of Clinical Oncology 2019","url":"https://doi.org/10.1200/JCO.18.01994"},{"label":"Risk-adapted DA-EPOCH-R in adult Burkitt lymphoma, Journal of Clinical Oncology 2020","url":"https://doi.org/10.1200/JCO.20.00303"},{"label":"NCI PDQ: adult non-Hodgkin lymphoma treatment (health professional)","url":"https://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq"}],"tags":[],"related":[],"cancers":["dlbcl","non-hodgkin-lymphoma","hodgkin-lymphoma","burkitt-lymphoma","mantle-cell-lymphoma","follicular-lymphoma","peripheral-t-cell-lymphoma","primary-cns-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":["rituximab","cyclophosphamide","doxorubicin","vincristine","prednisone","polatuzumab-vedotin","etoposide","bendamustine","lenalidomide","bleomycin","vinblastine","dacarbazine","procarbazine","brentuximab-vedotin","nivolumab","methotrexate","cytarabine","thiotepa","ifosfamide","carboplatin","cisplatin","gemcitabine","oxaliplatin","dexamethasone","asparaginase","bortezomib"],"companies":[],"institutions":[],"pathways":[],"terms":["r-chop","abvd-beacopp","lymphoma-tx-maintenance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/lymphoma-tx-regimen-alphabet/","neighbours":{"cancer":[{"id":"advanced-stage-classical-hodgkin-lymphoma","kind":"cancer","name":"Advanced-stage classical Hodgkin lymphoma (stage III to IV)","route":"/cancers/advanced-stage-classical-hodgkin-lymphoma/"},{"id":"burkitt-lymphoma","kind":"cancer","name":"Burkitt lymphoma","route":"/cancers/burkitt-lymphoma/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"early-stage-classical-hodgkin-lymphoma","kind":"cancer","name":"Early-stage classical Hodgkin lymphoma (stage I to II)","route":"/cancers/early-stage-classical-hodgkin-lymphoma/"},{"id":"follicular-lymphoma","kind":"cancer","name":"Follicular lymphoma","route":"/cancers/follicular-lymphoma/"},{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"},{"id":"mantle-cell-lymphoma","kind":"cancer","name":"Mantle cell lymphoma","route":"/cancers/mantle-cell-lymphoma/"},{"id":"angioimmunoblastic-t-cell-lymphoma","kind":"cancer","name":"Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic T-cell lymphoma)","route":"/cancers/angioimmunoblastic-t-cell-lymphoma/"},{"id":"nodular-lymphocyte-predominant-hodgkin-lymphoma","kind":"cancer","name":"Nodular lymphocyte-predominant Hodgkin lymphoma (nodular lymphocyte-predominant B-cell lymphoma)","route":"/cancers/nodular-lymphocyte-predominant-hodgkin-lymphoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"peripheral-t-cell-lymphoma","kind":"cancer","name":"Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma)","route":"/cancers/peripheral-t-cell-lymphoma/"},{"id":"primary-cns-lymphoma","kind":"cancer","name":"Primary CNS lymphoma","route":"/cancers/primary-cns-lymphoma/"},{"id":"primary-mediastinal-b-cell-lymphoma","kind":"cancer","name":"Primary mediastinal (thymic) large B-cell lymphoma","route":"/cancers/primary-mediastinal-b-cell-lymphoma/"},{"id":"relapsed-refractory-hodgkin-lymphoma","kind":"cancer","name":"Relapsed and refractory classical Hodgkin lymphoma","route":"/cancers/relapsed-refractory-hodgkin-lymphoma/"}],"drug":[{"id":"asparaginase","kind":"drug","name":"Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase)","route":"/drugs/asparaginase/"},{"id":"bendamustine","kind":"drug","name":"Bendamustine","route":"/drugs/bendamustine/"},{"id":"bleomycin","kind":"drug","name":"Bleomycin","route":"/drugs/bleomycin/"},{"id":"bortezomib","kind":"drug","name":"Bortezomib","route":"/drugs/bortezomib/"},{"id":"brentuximab-vedotin","kind":"drug","name":"Brentuximab vedotin","route":"/drugs/brentuximab-vedotin/"},{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"cyclophosphamide","kind":"drug","name":"Cyclophosphamide","route":"/drugs/cyclophosphamide/"},{"id":"cytarabine","kind":"drug","name":"Cytarabine","route":"/drugs/cytarabine/"},{"id":"dacarbazine","kind":"drug","name":"Dacarbazine","route":"/drugs/dacarbazine/"},{"id":"dexamethasone","kind":"drug","name":"Dexamethasone","route":"/drugs/dexamethasone/"},{"id":"doxorubicin","kind":"drug","name":"Doxorubicin","route":"/drugs/doxorubicin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"},{"id":"gemcitabine","kind":"drug","name":"Gemcitabine","route":"/drugs/gemcitabine/"},{"id":"ifosfamide","kind":"drug","name":"Ifosfamide","route":"/drugs/ifosfamide/"},{"id":"lenalidomide","kind":"drug","name":"Lenalidomide","route":"/drugs/lenalidomide/"},{"id":"methotrexate","kind":"drug","name":"Methotrexate","route":"/drugs/methotrexate/"},{"id":"nivolumab","kind":"drug","name":"Nivolumab","route":"/drugs/nivolumab/"},{"id":"oxaliplatin","kind":"drug","name":"Oxaliplatin","route":"/drugs/oxaliplatin/"},{"id":"polatuzumab-vedotin","kind":"drug","name":"Polatuzumab vedotin","route":"/drugs/polatuzumab-vedotin/"},{"id":"prednisone","kind":"drug","name":"Prednisone","route":"/drugs/prednisone/"},{"id":"procarbazine","kind":"drug","name":"Procarbazine","route":"/drugs/procarbazine/"},{"id":"rituximab","kind":"drug","name":"Rituximab","route":"/drugs/rituximab/"},{"id":"thiotepa","kind":"drug","name":"Thiotepa","route":"/drugs/thiotepa/"},{"id":"vinblastine","kind":"drug","name":"Vinblastine","route":"/drugs/vinblastine/"},{"id":"vincristine","kind":"drug","name":"Vincristine","route":"/drugs/vincristine/"}],"term":[{"id":"abvd-beacopp","kind":"term","name":"ABVD, BEACOPP and BrECADD (Hodgkin lymphoma regimens)","route":"/terms/abvd-beacopp/"},{"id":"lymphoma-tx-maintenance","kind":"term","name":"Maintenance and consolidation in lymphoma: where it works and where it does not","route":"/terms/lymphoma-tx-maintenance/"},{"id":"r-chop","kind":"term","name":"R-CHOP (lymphoma chemoimmunotherapy)","route":"/terms/r-chop/"}]}}