{"entity":{"id":"lyn","kind":"target","name":"LYN kinase","aka":[],"tldr":"LYN is a SRC-family kinase that sits under the B-cell receptor; dasatinib and bosutinib inhibit it alongside BCR-ABL, and LYN over-activity is one way chronic myeloid leukaemia escapes imatinib.","summary":"LYN is a SRC-family tyrosine kinase expressed in B cells and myeloid cells, where it both amplifies and restrains signalling from the B-cell receptor and cytokine receptors. In chronic myeloid leukaemia, over-expression of LYN is a recognised mechanism of imatinib resistance that does not involve a BCR-ABL mutation, and the second-generation inhibitors dasatinib and bosutinib block LYN and other SRC kinases directly. LYN is also constitutively active in chronic lymphocytic leukaemia cells, contributing to their survival.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/LYN_(gene)","links":[{"label":"UniProt P07948: LYN","url":"https://www.uniprot.org/uniprotkb/P07948/entry"},{"label":"HGNC:6735 LYN","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6735"},{"label":"ChEMBL target CHEMBL3905","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL3905"}],"tags":["chembl-gap"],"related":["bcr-abl","src"],"cancers":["cml","cll","aml"],"sections":[],"technologies":[],"targets":[],"drugs":["dasatinib","bosutinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"LYN","biology":"A membrane-anchored non-receptor tyrosine kinase; it phosphorylates immunoreceptor tyrosine motifs to start SYK signalling and also activates inhibitory phosphatases, giving it dual roles.","whereFound":["B lymphocytes and myeloid cells","Imatinib-resistant CML and CLL cells"],"targetClass":"kinase","prevalence":[]},"route":"/targets/lyn/","neighbours":{"target":[{"id":"bcr-abl","kind":"target","name":"BCR::ABL1 (Philadelphia chromosome)","route":"/targets/bcr-abl/"},{"id":"hck","kind":"target","name":"HCK kinase","route":"/targets/hck/"},{"id":"src","kind":"target","name":"SRC family kinases","route":"/targets/src/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"cml","kind":"cancer","name":"Chronic myeloid leukaemia (CML)","route":"/cancers/cml/"}],"drug":[{"id":"bosutinib","kind":"drug","name":"Bosutinib","route":"/drugs/bosutinib/"},{"id":"dasatinib","kind":"drug","name":"Dasatinib","route":"/drugs/dasatinib/"}]}}