{"entity":{"id":"macc1","kind":"target","name":"MACC1","aka":["MET transcriptional regulator MACC1","Metastasis-associated in colon cancer protein 1","7A5","SH3BP4L"],"tldr":"MACC1 (Metastasis-associated in colon cancer protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.","summary":"Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30215","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30215"},{"label":"UniProt Q6ZN28","url":"https://www.uniprot.org/uniprotkb/Q6ZN28/entry"},{"label":"NCBI Gene 346389","url":"https://www.ncbi.nlm.nih.gov/gene/346389"},{"label":"Ensembl ENSG00000183742","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183742"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MACC1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30215","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30215","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6ZN28","url":"https://www.uniprot.org/uniprotkb/Q6ZN28/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MACC1","url":"https://www.intogen.org/search?gene=MACC1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30215","ensembl":"ENSG00000183742","uniprot":"Q6ZN28","entrez":"346389","biology":"Acts as a transcription activator for MET and as a key regulator of HGF-MET signalling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumour growth and metastasis in vivo. Location: Cytoplasm; Nucleus (UniProt). Locus 7p21.1 (HGNC).","whereFound":["Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/macc1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}