{"entity":{"id":"maf","kind":"target","name":"MAF","aka":["MAF bZIP transcription factor","Transcription factor Maf","c-MAF"],"tldr":"MAF (Transcription factor Maf) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Multiple myeloma.","summary":"Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fibre cell differentiation.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes affected pathway 0.38, literature 0.82, genetic association 0.54, somatic mutation 0.81, animal model 0.76). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6776","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6776"},{"label":"UniProt O75444","url":"https://www.uniprot.org/uniprotkb/O75444/entry"},{"label":"NCBI Gene 4094","url":"https://www.ncbi.nlm.nih.gov/gene/4094"},{"label":"Ensembl ENSG00000178573","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178573"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["colorectal","multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAF","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6776","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6776","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75444","url":"https://www.uniprot.org/uniprotkb/O75444/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000178573","url":"https://platform.opentargets.org/target/ENSG00000178573/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.59 (GraphQL API, CC0)"},{"label":"IntOGen MAF","url":"https://www.intogen.org/search?gene=MAF","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6776","ensembl":"ENSG00000178573","uniprot":"O75444","entrez":"4094","biology":"Acts as a transcriptional activator or repressor. Involved in embryonic lens fibre cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fibre cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Location: Nucleus (UniProt). Locus 16q23.2 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.59 with colorectal cancer (MONDO_0005575)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/maf/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}]}}