{"entity":{"id":"mafb","kind":"target","name":"MAFB","aka":["MAF bZIP transcription factor B","Transcription factor MafB"],"tldr":"MAFB (Transcription factor MafB) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.89, animal model 0.26, genetic association 0.27, somatic mutation 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6408","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6408"},{"label":"UniProt Q9Y5Q3","url":"https://www.uniprot.org/uniprotkb/Q9Y5Q3/entry"},{"label":"NCBI Gene 9935","url":"https://www.ncbi.nlm.nih.gov/gene/9935"},{"label":"Ensembl ENSG00000204103","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204103"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAFB","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6408","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6408","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y5Q3","url":"https://www.uniprot.org/uniprotkb/Q9Y5Q3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000204103","url":"https://platform.opentargets.org/target/ENSG00000204103/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:6408","ensembl":"ENSG00000204103","uniprot":"Q9Y5Q3","entrez":"9935","biology":"Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific haematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. Location: Nucleus (UniProt). Locus 20q12 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mafb/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}