{"entity":{"id":"malt1","kind":"target","name":"MALT1","aka":["MALT1 paracaspase","Mucosa-associated lymphoid tissue lymphoma translocation protein 1","PCASP1"],"tldr":"MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer and Diffuse large B-cell lymphoma.","summary":"Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signalling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.04, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6819","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6819"},{"label":"UniProt Q9UDY8","url":"https://www.uniprot.org/uniprotkb/Q9UDY8/entry"},{"label":"NCBI Gene 10892","url":"https://www.ncbi.nlm.nih.gov/gene/10892"},{"label":"Ensembl ENSG00000172175","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172175"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["skin-cancer","dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["bcr-signalling"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MALT1","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6819","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6819","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UDY8","url":"https://www.uniprot.org/uniprotkb/Q9UDY8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000172175","url":"https://platform.opentargets.org/target/ENSG00000172175/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: skin cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen MALT1","url":"https://www.intogen.org/search?gene=MALT1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6819","ensembl":"ENSG00000172175","uniprot":"Q9UDY8","entrez":"10892","biology":"Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signalling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerisation and activation of its ligase activity. Location: Cytoplasm, perinuclear region; Nucleus (UniProt). Locus 18q21.32 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/malt1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"bcr-signalling","kind":"pathway","name":"B-cell receptor / BTK signalling (to NF-κB)","route":"/pathways/bcr-signalling/"}]}}