{"entity":{"id":"maml1","kind":"target","name":"MAML1","aka":["mastermind like transcriptional coactivator 1","Mastermind-like protein 1","KIAA0200","Mam-1"],"tldr":"MAML1 (Mastermind-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.88, affected pathway 0.94, genetic association 0.00, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13632","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13632"},{"label":"UniProt Q92585","url":"https://www.uniprot.org/uniprotkb/Q92585/entry"},{"label":"NCBI Gene 9794","url":"https://www.ncbi.nlm.nih.gov/gene/9794"},{"label":"Ensembl ENSG00000161021","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000161021"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAML1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13632","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13632","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92585","url":"https://www.uniprot.org/uniprotkb/Q92585/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000161021","url":"https://platform.opentargets.org/target/ENSG00000161021/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:13632","ensembl":"ENSG00000161021","uniprot":"Q92585","entrez":"9794","biology":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localisation of CREBBP to nuclear foci. Plays a role in haematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Location: Nucleus speckle (UniProt). Locus 5q35.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/maml1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}