{"entity":{"id":"maml3","kind":"target","name":"MAML3","aka":["mastermind like transcriptional coactivator 3","Mastermind-like protein 3","KIAA1816","MAM2","CAGH3","TNRC3"],"tldr":"MAML3 (Mastermind-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.\n\nOpen Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.30, affected pathway 0.94, genetic association 0.56).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16272","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16272"},{"label":"UniProt Q96JK9","url":"https://www.uniprot.org/uniprotkb/Q96JK9/entry"},{"label":"NCBI Gene 55534","url":"https://www.ncbi.nlm.nih.gov/gene/55534"},{"label":"Ensembl ENSG00000196782","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196782"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAML3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16272","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16272","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96JK9","url":"https://www.uniprot.org/uniprotkb/Q96JK9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196782","url":"https://platform.opentargets.org/target/ENSG00000196782/associations","note":"association with cancer (MONDO_0004992) 0.68;  (GraphQL API, CC0)"}],"hgnc":"HGNC:16272","ensembl":"ENSG00000196782","uniprot":"Q96JK9","entrez":"55534","biology":"Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Location: Nucleus speckle (UniProt). Locus 4q31.1 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/maml3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}