{"entity":{"id":"map3k1","kind":"target","name":"MAP3K1","aka":["mitogen-activated protein kinase kinase kinase 1","Mitogen-activated protein kinase kinase kinase 1","MAPKKK1","MEKK1"],"tldr":"MAP3K1 is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Selumetinib. Open Targets scores its association with cancer at 0.83 (direct and indirect evidence; datatypes genetic literature 0.38, clinical 0.06, literature 0.97, genetic association 0.61, somatic mutation 0.96, animal model 0.86). IntOGen calls it a driver in 19 cohorts (3 activating, 16 loss-of-function), covering Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cervical Adenocarcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Glioblastoma Multiforme and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6848","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6848"},{"label":"UniProt Q13233","url":"https://www.uniprot.org/uniprotkb/Q13233/entry"},{"label":"NCBI Gene 4214","url":"https://www.ncbi.nlm.nih.gov/gene/4214"},{"label":"Ensembl ENSG00000095015","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000095015"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["breast-cancer","ovarian","endometrial","rcc","colorectal","skin-cancer","cervical","hcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.06; IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 16 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAP3K1","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6848","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6848","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13233","url":"https://www.uniprot.org/uniprotkb/Q13233/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MAP3K1","url":"https://civicdb.org/features/3480","note":"1 evidence items, 0 assertions, 2 variants; diseases: Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000095015","url":"https://platform.opentargets.org/target/ENSG00000095015/associations","note":"association with cancer (MONDO_0004992) 0.83; per-cancer scores at or above 0.5: prostate cancer 0.55, ovarian cancer 0.64, endometrial cancer 0.56, skin cancer 0.58, breast cancer 0.77 (GraphQL API, CC0)"},{"label":"IntOGen MAP3K1","url":"https://www.intogen.org/search?gene=MAP3K1","note":"driver in 19 cohorts (Act 3, LoF 16); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6848","ensembl":"ENSG00000095015","uniprot":"Q13233","entrez":"4214","biology":"Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. Locus 5q11.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.77 with breast cancer (MONDO_0007254); IntOGen driver in 8 cohorts (BRCA)","Ovarian cancer: Open Targets association 0.64 with ovarian cancer (MONDO_0008170)","Endometrial cancer: Open Targets association 0.56 with endometrial cancer (MONDO_0011962); IntOGen driver in 2 cohorts (UCEC)","Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC)","Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD)","Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/map3k1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}