{"entity":{"id":"map3k13","kind":"target","name":"MAP3K13","aka":["mitogen-activated protein kinase kinase kinase 13","Mitogen-activated protein kinase kinase kinase 13","MEKK13"],"tldr":"MAP3K13 (Mitogen-activated protein kinase kinase kinase 13) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Breast cancer, Lung cancer and 1 more.","summary":"Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.00, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6852","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6852"},{"label":"UniProt O43283","url":"https://www.uniprot.org/uniprotkb/O43283/entry"},{"label":"NCBI Gene 9175","url":"https://www.ncbi.nlm.nih.gov/gene/9175"},{"label":"Ensembl ENSG00000073803","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073803"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","breast-cancer","lung-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAP3K13","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6852","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6852","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43283","url":"https://www.uniprot.org/uniprotkb/O43283/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000073803","url":"https://platform.opentargets.org/target/ENSG00000073803/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.55, breast cancer 0.53, lung cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:6852","ensembl":"ENSG00000073803","uniprot":"O43283","entrez":"9175","biology":"Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. Location: Cytoplasm; Membrane (UniProt). Locus 3q27.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/map3k13/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}