{"entity":{"id":"mapk1","kind":"target","name":"MAPK1","aka":["mitogen-activated protein kinase 1","Mitogen-activated protein kinase 1","ERK2","p41mapk","MAPK2","PRKM2","PRKM1"],"tldr":"MAPK1 is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signalling cascade initiated by activated KIT and KITLG/SCF.\n\nCIViC holds 5 clinical evidence items and 1 assertion across 3 variants, naming Erlotinib and WZ4002. Open Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes clinical 0.19, affected pathway 0.86, literature 0.99, genetic association 0.08, somatic mutation 0.95). IntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Cervical Squamous Cell Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Hepatocellular Carcinoma, Head and Neck Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6871"},{"label":"UniProt P28482","url":"https://www.uniprot.org/uniprotkb/P28482/entry"},{"label":"NCBI Gene 5594","url":"https://www.ncbi.nlm.nih.gov/gene/5594"},{"label":"Ensembl ENSG00000100030","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100030"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["head-and-neck","cervical","hcc","breast-cancer","skin-cancer","lung-cancer","nsclc","cll"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.19; IntOGen calls it an activating (Act) driver in 4 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 5 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAPK1","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6871","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P28482","url":"https://www.uniprot.org/uniprotkb/P28482/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MAPK1","url":"https://civicdb.org/features/4532","note":"5 evidence items, 1 assertions, 3 variants; diseases: Head And Neck Squamous Cell Carcinoma, Lung Non-small Cell Carcinoma, Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000100030","url":"https://platform.opentargets.org/target/ENSG00000100030/associations","note":"association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: cervical cancer 0.52, skin cancer 0.52, breast cancer 0.54, lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen MAPK1","url":"https://www.intogen.org/search?gene=MAPK1","note":"driver in 5 cohorts (Act 4, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6871","ensembl":"ENSG00000100030","uniprot":"P28482","entrez":"5594","biology":"Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signalling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Location: Cytoplasm, cytoskeleton, spindle; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm (UniProt). Locus 22q11.22 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (HNSC)","Cervical cancer: Open Targets association 0.52 with cervical cancer (MONDO_0002974); IntOGen driver in 2 cohorts (CESC)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/mapk1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}