{"entity":{"id":"mark2","kind":"target","name":"MARK2","aka":["microtubule affinity regulating kinase 2","Serine/threonine-protein kinase MARK2","PAR-1","Par1b","PAR-1B","EMK1"],"tldr":"MARK2 (Serine/threonine-protein kinase MARK2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.","summary":"Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3332","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3332"},{"label":"UniProt Q7KZI7","url":"https://www.uniprot.org/uniprotkb/Q7KZI7/entry"},{"label":"NCBI Gene 2011","url":"https://www.ncbi.nlm.nih.gov/gene/2011"},{"label":"Ensembl ENSG00000072518","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072518"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MARK2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:3332","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3332","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7KZI7","url":"https://www.uniprot.org/uniprotkb/Q7KZI7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MARK2","url":"https://www.intogen.org/search?gene=MARK2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:3332","ensembl":"ENSG00000072518","uniprot":"Q7KZI7","entrez":"2011","biology":"Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Location: Cell membrane; Cytoplasm; Lateral cell membrane; Cytoplasm, cytoskeleton (UniProt). Locus 11q13.1 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/mark2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}