{"entity":{"id":"mark3","kind":"target","name":"MARK3","aka":["microtubule affinity regulating kinase 3","MAP/microtubule affinity-regulating kinase 3","CTAK1","KP78","PAR-1A"],"tldr":"MARK3 (MAP/microtubule affinity-regulating kinase 3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.97, genetic association 0.22).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6897","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6897"},{"label":"UniProt P27448","url":"https://www.uniprot.org/uniprotkb/P27448/entry"},{"label":"NCBI Gene 4140","url":"https://www.ncbi.nlm.nih.gov/gene/4140"},{"label":"Ensembl ENSG00000075413","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075413"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MARK3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6897","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6897","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P27448","url":"https://www.uniprot.org/uniprotkb/P27448/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000075413","url":"https://platform.opentargets.org/target/ENSG00000075413/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6897","ensembl":"ENSG00000075413","uniprot":"P27448","entrez":"4140","biology":"Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localisation and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localisation and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Location: Cell membrane; Cell projection, dendrite; Cytoplasm (UniProt). Locus 14q32.32-q32.33 (HGNC).","whereFound":[],"targetClass":"kinase","prevalence":[]},"route":"/targets/mark3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}