{"entity":{"id":"max","kind":"target","name":"MAX","aka":["MYC associated transcriptional regulator X","bHLHd4","bHLHd5","bHLHd6","bHLHd7","bHLHd8"],"tldr":"MAX (MYC associated transcriptional regulator X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Multiple myeloma, Endometrial cancer and 5 more.","summary":"Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognises the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.17, somatic mutation 0.95). IntOGen calls it a driver in 10 cohorts (7 activating, 3 loss-of-function), covering Invasive Breast Carcinoma, Gastrointestinal Stromal Tumour, Low-Grade Glioma, NOS, Medulloblastoma, Pilocytic Astrocytoma, Plasma Cell Myeloma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6913","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6913"},{"label":"UniProt P61244","url":"https://www.uniprot.org/uniprotkb/P61244/entry"},{"label":"NCBI Gene 4149","url":"https://www.ncbi.nlm.nih.gov/gene/4149"},{"label":"Ensembl ENSG00000125952","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125952"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["neuroendocrine","multiple-myeloma","endometrial","breast-cancer","small-bowel","colorectal","skin-cancer","gist"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["myc"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 7 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MAX","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6913","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6913","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P61244","url":"https://www.uniprot.org/uniprotkb/P61244/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000125952","url":"https://platform.opentargets.org/target/ENSG00000125952/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.53, melanoma 0.52, neuroendocrine neoplasm 0.76, plasma cell myeloma 0.51, skin cancer 0.53, breast cancer 0.55 (GraphQL API, CC0)"},{"label":"IntOGen MAX","url":"https://www.intogen.org/search?gene=MAX","note":"driver in 10 cohorts (Act 7, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6913","ensembl":"ENSG00000125952","uniprot":"P61244","entrez":"4149","biology":"Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognises the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. Location: Nucleus; Cell projection, dendrite (UniProt). Locus 14q23.3 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.76 with neuroendocrine neoplasm (MONDO_0019496)","Multiple myeloma: Open Targets association 0.51 with plasma cell myeloma (MONDO_0009693); IntOGen driver in 2 cohorts (PCM)","Endometrial cancer: IntOGen driver in 2 cohorts (UCEC)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Small intestine cancer: IntOGen driver in 1 cohort (SIC)","Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/max/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gist","kind":"cancer","name":"Gastrointestinal stromal tumour (GIST)","route":"/cancers/gist/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"},{"id":"small-bowel","kind":"cancer","name":"Small intestine cancer (small bowel adenocarcinoma)","route":"/cancers/small-bowel/"}],"pathway":[{"id":"myc","kind":"pathway","name":"MYC","route":"/pathways/myc/"}]}}