{"entity":{"id":"mb21d2","kind":"target","name":"MB21D2","aka":["Mab-21 domain containing 2","Nucleotidyltransferase MB21D2","D2A","C3orf59"],"tldr":"MB21D2 (Nucleotidyltransferase MB21D2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Sarcomas, Bladder & urothelial cancer and 2 more.","summary":"Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus.\n\nIntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Liposarcoma, Lung Squamous Cell Carcinoma, Upper Tract Urothelial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30438","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30438"},{"label":"UniProt Q8IYB1","url":"https://www.uniprot.org/uniprotkb/Q8IYB1/entry"},{"label":"NCBI Gene 151963","url":"https://www.ncbi.nlm.nih.gov/gene/151963"},{"label":"Ensembl ENSG00000180611","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000180611"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["head-and-neck","sarcoma","urothelial","liposarcoma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MB21D2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30438","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30438","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IYB1","url":"https://www.uniprot.org/uniprotkb/Q8IYB1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MB21D2","url":"https://www.intogen.org/search?gene=MB21D2","note":"driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30438","ensembl":"ENSG00000180611","uniprot":"Q8IYB1","entrez":"151963","biology":"Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. Locus 3q29 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Sarcomas: IntOGen driver in 1 cohort (LIPO)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)","Liposarcoma: IntOGen driver in 1 cohort (LIPO)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/mb21d2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}