{"entity":{"id":"mcl1","kind":"target","name":"MCL1","aka":["MCL1 apoptosis regulator, BCL2 family member","Induced myeloid leukemia cell differentiation protein Mcl-1","BCL2L3","Mcl-1"],"tldr":"MCL1 (Induced myeloid leukaemia cell differentiation protein Mcl-1) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Multiple myeloma.","summary":"Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Mcl-1 Inhibitor MIK665. In OnCo, 1 product record names it (Omacetaxine mepesuccinate).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6943","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6943"},{"label":"UniProt Q07820","url":"https://www.uniprot.org/uniprotkb/Q07820/entry"},{"label":"NCBI Gene 4170","url":"https://www.ncbi.nlm.nih.gov/gene/4170"},{"label":"Ensembl ENSG00000143384","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143384"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":["omacetaxine"],"companies":[],"institutions":[],"pathways":["apoptosis-bcl2","mrna-translation-eif4f","transcription-addiction"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MCL1","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6943","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6943","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q07820","url":"https://www.uniprot.org/uniprotkb/Q07820/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MCL1","url":"https://civicdb.org/features/3448","note":"1 evidence items, 0 assertions, 1 variants; diseases: Multiple Myeloma (GraphQL API, CC0)"}],"hgnc":"HGNC:6943","ensembl":"ENSG00000143384","uniprot":"Q07820","entrez":"4170","biology":"Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Location: Membrane; Cytoplasm; Mitochondrion; Nucleus, nucleoplasm (UniProt). Locus 1q21.2 (HGNC).","whereFound":["Multiple myeloma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/mcl1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"drug":[{"id":"omacetaxine","kind":"drug","name":"Omacetaxine mepesuccinate","route":"/drugs/omacetaxine/"}],"pathway":[{"id":"apoptosis-bcl2","kind":"pathway","name":"Intrinsic apoptosis (BCL-2 family)","route":"/pathways/apoptosis-bcl2/"},{"id":"mrna-translation-eif4f","kind":"pathway","name":"mRNA translation (eIF4F / mTOR)","route":"/pathways/mrna-translation-eif4f/"},{"id":"transcription-addiction","kind":"pathway","name":"Transcriptional machinery & addiction","route":"/pathways/transcription-addiction/"}]}}