{"entity":{"id":"mcm7","kind":"target","name":"MCM7","aka":["minichromosome maintenance complex component 7","DNA replication licensing factor MCM7","CDC47","PPP1R104","MCM2"],"tldr":"MCM7 (DNA replication licensing factor MCM7) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer.","summary":"Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Cervical Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6950","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6950"},{"label":"UniProt P33993","url":"https://www.uniprot.org/uniprotkb/P33993/entry"},{"label":"NCBI Gene 4176","url":"https://www.ncbi.nlm.nih.gov/gene/4176"},{"label":"Ensembl ENSG00000166508","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166508"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["cervical"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MCM7","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6950","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6950","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P33993","url":"https://www.uniprot.org/uniprotkb/P33993/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MCM7","url":"https://www.intogen.org/search?gene=MCM7","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6950","ensembl":"ENSG00000166508","uniprot":"P33993","entrez":"4176","biology":"Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Location: Nucleus; Chromosome (UniProt). Locus 7q22.1 (HGNC).","whereFound":["Cervical cancer: IntOGen driver in 1 cohort (CESC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/mcm7/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"}]}}