{"entity":{"id":"mdga2","kind":"target","name":"MDGA2","aka":["MAM domain containing glycosylphosphatidylinositol anchor 2","MAM domain-containing glycosylphosphatidylinositol anchor protein 2","MAMDC1"],"tldr":"MDGA2 (MAM domain-containing glycosylphosphatidylinositol anchor protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.","summary":"May be involved in cell-cell interactions.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19835","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19835"},{"label":"UniProt Q7Z553","url":"https://www.uniprot.org/uniprotkb/Q7Z553/entry"},{"label":"NCBI Gene 161357","url":"https://www.ncbi.nlm.nih.gov/gene/161357"},{"label":"Ensembl ENSG00000139915","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139915"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MDGA2","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:19835","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19835","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z553","url":"https://www.uniprot.org/uniprotkb/Q7Z553/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MDGA2","url":"https://www.intogen.org/search?gene=MDGA2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:19835","ensembl":"ENSG00000139915","uniprot":"Q7Z553","entrez":"161357","biology":"May be involved in cell-cell interactions. Location: Cell membrane (UniProt). Locus 14q21.3 (HGNC).","whereFound":["Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/mdga2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}