{"entity":{"id":"mdm4","kind":"target","name":"MDM4","aka":["MDM4 regulator of p53"],"tldr":"MDM4 (MDM4 regulator of p53) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Prostate cancer and 1 more.","summary":"Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Nivolumab, Pembrolizumab and Atezolizumab. Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes affected pathway 0.57, literature 0.99, genetic association 0.60, somatic mutation 0.97, animal model 0.49).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6974","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6974"},{"label":"UniProt O15151","url":"https://www.uniprot.org/uniprotkb/O15151/entry"},{"label":"NCBI Gene 4194","url":"https://www.ncbi.nlm.nih.gov/gene/4194"},{"label":"Ensembl ENSG00000198625","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198625"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["skin-cancer","breast-cancer","prostate","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["p53-mdm2-axis"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MDM4","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6974","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6974","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15151","url":"https://www.uniprot.org/uniprotkb/O15151/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MDM4","url":"https://civicdb.org/features/3466","note":"2 evidence items, 0 assertions, 2 variants; diseases: Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000198625","url":"https://platform.opentargets.org/target/ENSG00000198625/associations","note":"association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: prostate cancer 0.55, melanoma 0.59, skin cancer 0.56, breast cancer 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:6974","ensembl":"ENSG00000198625","uniprot":"O15151","entrez":"4194","biology":"Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. Location: Nucleus; Cytoplasm (UniProt). Locus 1q32.1 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315)","Melanoma: Open Targets association 0.59 with melanoma (MONDO_0005105)"],"targetClass":"other","prevalence":[]},"route":"/targets/mdm4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"p53-mdm2-axis","kind":"pathway","name":"The p53 network (guardian of the genome)","route":"/pathways/p53-mdm2-axis/"}]}}