{"entity":{"id":"med23","kind":"target","name":"MED23","aka":["mediator complex subunit 23","Mediator of RNA polymerase II transcription subunit 23","CRSP130","DRIP130","Sur2","CRSP3","MRT18"],"tldr":"MED23 (Mediator of RNA polymerase II transcription subunit 23) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.","summary":"Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2372","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2372"},{"label":"UniProt Q9ULK4","url":"https://www.uniprot.org/uniprotkb/Q9ULK4/entry"},{"label":"NCBI Gene 9439","url":"https://www.ncbi.nlm.nih.gov/gene/9439"},{"label":"Ensembl ENSG00000112282","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112282"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MED23","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2372","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2372","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9ULK4","url":"https://www.uniprot.org/uniprotkb/Q9ULK4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MED23","url":"https://www.intogen.org/search?gene=MED23","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2372","ensembl":"ENSG00000112282","uniprot":"Q9ULK4","entrez":"9439","biology":"Required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signalling. Location: Nucleus (UniProt). Locus 6q23.2 (HGNC).","whereFound":["Breast cancer: IntOGen driver in 1 cohort (BRCA)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/med23/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}