{"entity":{"id":"mib2","kind":"target","name":"MIB2","aka":["MIB E3 ubiquitin protein ligase 2","E3 ubiquitin-protein ligase MIB2","skeletrophin","ZZZ5","FLJ39787","ZZANK1"],"tldr":"MIB2 (E3 ubiquitin-protein ligase MIB2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma.","summary":"E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signalling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30577","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30577"},{"label":"UniProt Q96AX9","url":"https://www.uniprot.org/uniprotkb/Q96AX9/entry"},{"label":"NCBI Gene 142678","url":"https://www.ncbi.nlm.nih.gov/gene/142678"},{"label":"Ensembl ENSG00000197530","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197530"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MIB2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30577","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30577","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96AX9","url":"https://www.uniprot.org/uniprotkb/Q96AX9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MIB2","url":"https://www.intogen.org/search?gene=MIB2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30577","ensembl":"ENSG00000197530","uniprot":"Q96AX9","entrez":"142678","biology":"E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signalling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Location: Cytoplasm; Endosome (UniProt). Locus 1p36.33 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/mib2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}]}}