{"entity":{"id":"mien1","kind":"target","name":"MIEN1","aka":["migration and invasion enhancer 1","C17orf37","C35"],"tldr":"MIEN1 is a small HER2-amplicon gene whose protein promotes cell migration and is strongly raised in breast and prostate cancers.","summary":"17q12 HER2 amplicon neighbour: co-amplified and co-expressed with ERBB2 in HER2-positive breast and gastric cancer, so it appears in HER2-enriched expression signatures as a passenger of the amplification rather than a driver of its own. UniProt notes that MIEN1 is nearly absent from normal tissue outside the testis yet strongly up-regulated in breast cancer and in higher-grade prostate cancer, which makes it one of the more interesting passengers.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:28230","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28230"},{"label":"UniProt Q9BRT3","url":"https://www.uniprot.org/uniprotkb/Q9BRT3/entry"}],"tags":["cansim-terms"],"related":["her2"],"cancers":["breast-cancer","prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["co-amplification","cancer-ai-vocabulary"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"MIEN1","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28230","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28230","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt Q9BRT3","url":"https://www.uniprot.org/uniprotkb/Q9BRT3/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:28230","ensembl":"ENSG00000141741","uniprot":"Q9BRT3","entrez":"84299","biology":"Increases cell migration by inducing filopodia at the leading edge; regulates apoptosis, possibly through CASP3; among normal tissues present only in Leydig cells, strongly up-regulated in breast cancers and higher-grade prostate adenocarcinoma at the protein level (UniProt Q9BRT3).","whereFound":["Locus 17q12 (HGNC)."],"targetClass":"other","prevalence":[]},"route":"/targets/mien1/","neighbours":{"target":[{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"}]}}